Selective IgA deficiency, juvenile idiopathic arthritis and anterior uveitis in a Costa Rican child. Coincidental diseases?. Case report and literature review

Backgroup: selective IgA deficiency is the most frequent primary immunodeficiency worldwide. Patients are usually asymptomatic. However, those cases with symptoms develop recurrent infections and increased risk of autoimmune malignant diseases. On other hand, rheumatic disorders uncommon during childhood juvenile idiopathic arthritis as common one. Case Presentation: we present case a female patient, who developed oligoarticular at age 7 years. After diagnosis, she acute anterior uveitis. During initial immunological evaluation, diagnosis was confirmed. A work-up for demonstrated normal T cell compartment. B subpopulations showed memory lymphocytes, absence transitional cells, an increase in CD21 low unique subset. Conclusions: beginning any rheumatological physician should request immunoglobulins levels, order to detect possible antibodies deficiencies.